Principal Technical Project Manager ( we have office locations in Cambridge, Leeds & London)

Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.

Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.

We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.

Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.

We're on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime – from birth to old age.

We are seeking a Principal Technical Project Manager to help deliver and enhance modern on-premise and cloud-based infrastructure supporting world-leading genomics diagnostics and research. In this role, you will work closely with the Scalable Service Lead and leadership team to guide multiple interdependent technical workstreams, ensuring delivery aligns with programme objectives, governance frameworks, and PMO standards.
You will collaborate across squads, suppliers, and partners, while supporting the Service Owner in coordinating technical platform delivery and managing third-party contributions. This senior role suits someone with strong technical understanding, excellent stakeholder engagement skills, and experience delivering complex platforms in regulated or data-intensive environments, with a collaborative and inclusive approach to delivery.

Everyday responsibilities include:

• Lead end-to-end delivery of key technical areas within the programme, taking ownership while fostering a collaborative, supportive delivery environment.
• Partner with the Product Manager and/or Service Owner to validate and agree requirements, ensuring alignment with timelines, budgets, and OKRs.
• Establish and maintain delivery plans, tracking progress and communicating clearly where adjustments or support are needed.
• Proactively identify and resolve issues, working closely with teams to remove blockers and enable successful outcomes.
• Create and manage RAID (Risks, Actions, Issues, and Dependencies) logs, regularly reviewing and coordinating follow-up actions.
• Produce clear, concise status updates and contribute to programme and board-level reporting where required.
• Support structured and inclusive decision-making processes, ensuring the right stakeholders are engaged at the right time.
• Apply appropriate governance to meet internal and external standards, including cybersecurity, data protection, data quality, and regulatory requirements.
• Ensure transparent, thoughtful communication so delivery teams understand priorities, timelines, and expectations, while keeping stakeholders informed.
• Build positive relationships with internal and external stakeholders, managing escalations. constructively and facilitating respectful conflict resolution when needed.

Skills and experience for success:

• Project, risk, and issue management with a proactive and solutions-focused approach.
• Strong communication skills, engaging effectively with both technical and non-technical audiences.
• Commercial awareness and financial understanding to support informed decision-making.
• Stakeholder management, building trusted relationships across teams and leadership levels.
• Confident decision-making with sound judgement on escalation and risk management.
• Ability to translate complex technical concepts into clear, accessible language for non-technical stakeholders.
• Collaborative approach to problem-solving, balancing delivery priorities with business needs.

Exposure of the following technologies:

• AWS ecosystem, including core infrastructure services such as EC2, S3, RDS and IAM.
• Understanding of AWS architecture tools and services such as Lambda, EKS, VPC and Direct Connect.
• Experience or awareness of operational and infrastructure-as-code tools including CloudFormation, Terraform and CloudWatch.
• Exposure to AWS data and analytics services such as Glue, Redshift and Step Functions.

Whilst Project Management certifications are desirable, we are mostly interested in your experience.

Salary from: £77,000

Closing date for applications - Tuesday 14th April 2026 

Being an integral part of such a meaningful mission is extremely rewarding in itself, but in order to support our people, we’re continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals, as well as offering a benefits package including: 

• Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
• Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
• Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), and a Give As You Earn scheme.
• Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
• Recognition & Rewards: Employee recognition programme and referral scheme.
• Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.

Equal opportunities and our commitment to a diverse and inclusive workplace 

Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background. 

Genomics England’s policies of non-discrimination and equity and will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor.  

Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity. 

We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us. 

Culture

We have four key behaviours that represent what we would like Genomics England to feel like and the culture we want to encourage, in order for us to achieve our mission. These behaviours help us all work well together, deliver on our outcomes, celebrate our successes and share feedback with each other. You can read about these and other aspects of our culture here Culture | Genomics England

Blended working model

Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However, this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to, however, some of our roles require full time on site attendance e.g., lab teams, reception team. 

Our teams and squads have, and will continue to reflect on what works best for them to work together successfully and have the freedom to design working patterns to suit, beyond the minimum. Our office locations are: Canary Wharf, Cambridge and Leeds.

Onboarding background checks

As part of our recruitment process, all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check.  We therefore require applicants to disclose any previous offences at point of application, as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.