Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
The Commercial Ops & Analytics Manager will play a critical role in establishing and driving commercial excellence across the UK organization. This position is responsible for optimizing sales force strategy, performance, and execution through data-driven insights, advanced analytics, incentive compensation design, and field effectiveness initiatives.
The role partners closely with UK Head of Commercial and their sales leadership, Marketing, Medical, Finance, and Global & regional commercial teams to ensure the UK field organization is aligned, productive, and prepared to achieve launch and growth objectives.
Key Responsibilities
Sales Force Strategy & Optimization
- Advise and support sales force sizing, structure, and territory alignment in line with business objectives and market dynamics
- Develop and maintain call planning, targeting, and segmentation strategies in collaboration with UK Head of Commercial and sales leadership
- Continuously assess field deployment effectiveness and recommend improvements
Performance Analytics & Reporting
- Design and deliver dashboards, KPIs, and performance reports for UK leadership
- Analyze sales results, field activity, and promotional effectiveness to generate actionable insights
- Support forecasting, trend analysis, and scenario planning and market research analysis (in collaboration with marketing)
Incentive Compensation
- Lead the design, implementation, and administration of incentive compensation plans for review and approval by UK leadership
- Ensure alignment of incentives with strategic priorities and compliance requirements
- Partner with Finance and HR on goal setting, payout calculations, and plan communication
Field Effectiveness & Execution
- Drive initiatives to improve sales force productivity, capability, and execution quality
- Support CRM optimization adoption and use for clear business benefit (e.g., Veeva CRM) and optimal customer experience
- Collaborate with sales management to identify performance gaps and learning opportunities
Cross-Functional Collaboration
- Act as a trusted thought partner to UK Leadership and Commercial, Medical and Access stakeholders
- Align local SFE initiatives with any Regional or Global Commercial Excellence standards
- Support all launch readiness and post-launch optimization activities cross functionally as needed
Qualifications & Experience
Required
- Bachelor’s /Master degree in Business, Life Sciences, Analytics, or a related field such as Finance
- 8+ years of experience in Sales Force Effectiveness, Commercial Excellence, or Analytics within the pharmaceutical or biotech industry
- Strong expertise in incentive compensation, field analytics, and CRM systems
- Proven ability to translate data into strategic recommendations
- Experience working cross-functionally in a matrix organization
- Fluent in English
- Launch experience in specialty or rare disease markets
- Experience working with global or regional commercial teams
- Strong knowledge of the UK pharmaceutical market and compliance environment
Key Competencies
- Strategic and analytical mindset
- High attention to detail and operational excellence
- Strong stakeholder management and communication skills
- Ability to influence without authority
- Hands-on, proactive, and solution-oriented approach
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected].
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.
Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].
